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Methadone (Dolophine, Amidone, Methadose, Physeptone, Heptadon and many others) is a synthetic opioid, used medically as an analgesic, antitussive and a maintenance anti-addictive for use contained by patients on opioids. It was developed in Germany within 1937. Although chemically unlike morphine or heroin, methadone also acts on the opioid receptors and thus produces many of impossible to tell apart effects. Methadone is also used in managing chronic pain due to its long duration of handling and very low cost. In late 2004, the cost of a one-month supply of methadone be $20, as compared to an equivalent analgesic amount of Demerol (pethidine) at $120, up to $500 and more for Palladone (hydromorphone), MS-Contin (morphine) and Duragesic (fentanyl) as well as the Opana series of extended-release oxymorphone.
Methadone's usefulness in treatment of opioid dependence is the result of its cross-tolerance beside other opioids including heroin, morphine, etc. and long duration of effects with the result that oral dosing with methadone will stabilise the condition of the long-suffering by stopping and preventing the opioid withdrawal syndrome and getting patients off the syringe by at least partially blocking the "rush" resulting from intravenous injection of heroin, morphine, and similar drugs.

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