What is the difference between hydrocodone and codeine?
Answers:
I sprained my ankle two days ago. why does it...?
Hi,There are a couple of difference between these 2 molecules.
1) Potency: Codeine is a weak agonist. (It activates the opiate receptors weakly.) It is 20 times weaker than Morphine. Hydrocodone is a moderate strength agonist. It is 5 times more potent than codeine, or 4 times weaker than Morphine.
2) Efficacy: Given that Codeine solely binds weakly to the opiate receptors, it is not very efficacious as a pain reliever. Hydrocodone is far more efficacious.
3) Chemical Structure: You an give somebody a lift a look at both their chemical structures on wiki. There are 2 differences between the Codeine and Hydrocodone molecules.
(Structurally, Hydrocodone is 7,8-dihydrocodein-6-one. It is a codeine molecule with 2 modifications. If you have studied chemistry previously, the 7,8 double bond on the cyclohexene ring is first saturated yielding dihydrocodeine. Next, the 6-position is modified to concede a ketone, forming dihydrocodeinone or hydrocodone.)
Given that their potency varies, the dosage can be calculated like this:
200mg Codeine (oral) = 40mg Hydrocodone (oral) = 30mg Morphine (oral) = 10 mg Morphine (IV/IM)
Hope this help. Drop me a line if you need.
EDIT: 5 Tablets of T3 is agency MORE than 10mg of hydrocodone. A more accurate figure would be:
10mg hydrocodone = 50mg Codeine
Chemically related, they are in one and the same class. The Hydrocodone is commonly known as Vicodin. The highest dose of hydrocodone is 10mg the doctor be talking about. There are also frequent combinations of hydrocodone products, known as Vicodin, Lortab, Norco, Maxicodone, Xodol, and Zydone. The hydrocodone dose ranges from 2.5mg of hydrocodone to 10mg of hydrocodone, with assorted doses of acetaminophen. Tylenol w. Codeine, or, Tylenol #3, is a much weaker narcotic analgesic used for mild to moderate severe twinge. There is 30mg of Codeine and 300mg of tylenol. There is also a tylenol #4, with 60mg of Codeine and 300mg of tylenol. You would honestly need 5 or more tablets of tylenol w. Codeine #3 to equal 10mg of hydrocodone.
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